How To Help Mounjaro Fatigue & Feeling Cold
Two of the most common side effects we hear from clients when taking Mounjaro are feeling cold on Mounjaro and being tired.
For the majority of people, feeling tired on Mounjaro or cold isn’t anything to worry about and is simply your body’s reaction to the medication and how it changes your digestion, metabolism, and appetite.
Luckily, there are some tips that can help you boost your energy and stay warm while taking Mounjaro.

Why Does Mounjaro Fatigue Happen?
Mounjaro fatigue is a common side effect that can occur while taking the medication, especially in the first few weeks as your body adapts to it.
There are a few factors which can contribute to being tired on Mounjaro, such as –
- Blood sugar fluctuations – Since Mounjaro helps lower your blood sugar levels, this can lower your energy levels as they dip and rise after eating till your body adjusts.
- Appetite suppression – You will naturally eat less on Mounjaro since it suppresses your appetite, which means you are consuming fewer calories to use as energy.
- Hormonal changes – Mounjaro can affect the hormones that regulate your energy levels, mimicking GLP-1 and GIP.
- Metabolism effects – Slower digestion means you are getting energy from your food more slowly; this delay can lead to lower energy levels compared to when you weren’t taking Mounjaro.
Why You Are Feeling Cold On Mounjaro
Since Mounjaro reduces your calorie intake, this can slow your metabolism down so that your body conserves energy, which can lead to feeling colder in your hands and feet, as well as lower body fat, making it harder to stay warm since you have less fat as insulation.
Hormonal changes can impact thermogenesis, too, which is your body’s way of producing heat after eating. Slower digestion means a reduced thermic effect of the food you are eating.
How To Boost Energy While Taking Mounjaro
There are some ways you can help with Mounjaro fatigue and feel like yourself again. We recommend trying the following tips to see how they improve your energy.
- Eat nutrient-dense meals – Focus on eating meals that have a good mix of protein, healthy fats, and complex carbs. These can help to stabilise your blood sugar and keep you full.
- Keep a good sleep schedule – Having a consistent sleep schedule is important so your body can rest, especially if you are in a calorie deficit and losing fat.
- Hydrate – Drinking water is key to supporting your metabolism and will help boost energy levels.
- Keep an eye on your vitamin levels – Your fatigue might be linked to low iron levels, low vitamin B12 or magnesium. Checking your levels with a doctor and supplementing can combat this. We offer IV nutrition therapy to help with fatigue at our clinic.
- Exercise – Making sure you go on a daily walk each day will help boost your energy levels even if you don’t feel like exercising.

How To Stay Warm On Mounjaro
Feeling cold on Mounjaro can be uncomfortable, especially during the colder months.
Some tips we suggest to our clients on Mounjaro are –
- Movement – Physical activity like stretching and walking can help with circulation which can in turn help your body stay warm, sitting still for long periods slows circulation and blood flow.
- Wear layers – Layering with thermals can help trap heat in your body.
- Consume warm food and drinks – Warm drinks and meals can stimulate thermogenesis in the body and increase body temperature.
- Keep your environment warm – Keep a warm room temperature of around 20-22 degrees and buy electric blankets to keep you warm when resting.

Are The Side Effects Of Mounjaro Temporary?
Feeling fatigued and cold from Mounjaro is common and mostly temporary, occurring in the first few weeks after taking the medication while your body adjusts to the side effects.
We recommend following the tips above to help cope with the adjustment period while your metabolism stabilises and your body gets used to Mounjaro.
If Mounjaro fatigue is affecting your daily activities, lasts for longer than a month, or you are feeling extreme cold, you should speak to your GP to identify potential causes, whether the solution is adjusting the dosage or supplementing with vitamins.